DNA Reverse Complement Tool

Generate reverse complement sequences with case preservation

Enter DNA sequence:

Preserve case

Reverse Complement Result

Reverse Complement DNA Sequence Tool

Our free reverse complement tool generates the complementary DNA sequence in reverse orientation, an essential operation in molecular biology and bioinformatics. The DNA reverse complement is crucial for primer design, sequence alignment, and understanding DNA structure. This tool performs sequence cleaning automatically, removing whitespace and formatting your input for analysis.

The reverse complement operation reverses the sequence and replaces each nucleotide with its complement: A↔T and G↔C. Our tool supports case preservation, allowing you to maintain the original case of your sequence if needed. This feature is particularly useful when working with sequences that have specific case conventions for different regions or features. Use our main sequence analyzer for comprehensive analysis, or explore our GC content calculator and DNA translation tool for additional sequence analysis capabilities.

All processing is performed instantly in your browser with complete privacy - no data leaves your computer. The reverse complement tool is perfect for researchers, students, and professionals working with DNA sequences in sequence analysis, genome analysis, and molecular biology applications.

Last updated: